R&D Pipeline
We develop prototypes of medical devices and equipment using antigen ligands for customers' internal testing. We provide advanced technical and scientific assistance based on our many years of experience to support our client’s product development.
Grafted cellulose : BAR
BAR stands for Blood-group Antibody Remover. This is tetraose blood group antigen sugar immobilized on a cellulosic support.
It exists under two versions: BAR-A and BAR-B; the BAR molecule is represented here below in it’s A version:
This product has been designed to be disposable (once the blood group antibodies are captured and fixed on the BAR molecule, the product of interest is filtered and the used BAR product is thrown away.
This approach is made possible by the low cost approaches that have been chosen in the product design and the high production scale of the sugars themselves.
Note however that BAR can be recycled thanks to 1M NaOH washing solution.
GlycoBAR is owning a patent on the grafting process.
GlycoBAR is currently developing a proof of concept of a device capable of removing blood group antibodies from a PRP solution without filtration.
Platelets Bag :
Platelets are usually provided in a solution of plasma (called PRP for Plasma Rich Platelets).
In order for the platelets to be universal (not group dependent) plasma has be free of blood group antibodies.
But filtering in a “classic” way a solution of plasma containing platelets is not a trivial task because platelets tend to activate when they are filtered.
Countertyping and antibody titration
When blood group must be figured out, this is done in two steps :
The first one is “grouping” where the blood is tested against known blood group antibodies.
The second one is “counter typing” where plasma is tested against known red blood cell.
This second step is not an easy one because of the red blood cells (RBC) which are needed.
The RBC being a natural biological product, they tend to vary from one batch to the following and even if they come in a freeze-dried form, their life time is relatively short GlycoBAR has designed another way of counter typing which doesn’t involve red blood cells and which brings another huge benefit: titration of blood group antibodies.
The titration is obtained simply by reading an Elisa plate in a way that is fully compatible with any kind of Elisa plate readers that are already available in plasma collection centers.
This titration device has been developed for allowing plasma collection centers to eliminate plasma bags which blood group antibody titer is too high versus the max titer that can be eliminated for a Universal Plasma filter.
Emergency Solution (new AB substance):
Until mad cow crisis, hospitals were using a so called “AB substance” which allowed them to neutralize anti-A and anti-B antibodies from patient’s blood in many different prescription cases.
This AB substance was extracted from bovine intestines and had been therefore forbidden after the mad cow crises because of potential prion presence in this substance that was deemed prone to trigger Creutzfeldt-Jakob encephalopathy.
It is now possible to use again such a liquid solution that GlycoBAR can provide to neutralize anti-A and anti-B antibodies thus preventing hemolysis risk in many prescription cases.